![]() |
|
| Normal
Mouse Average systolic pressure = 125 mmHg Average diastolic pressure = 90 mmHg Average mean pressure = 111 mmHg Heart rate = 580 beats per minute
|
DBH
Knockout Mouse Average systolic pressure = 81 mmHg Average diastolic pressure = 76 mmHg Average mean pressure = 64 mmHg Heart rate = 390 beats per minute |
|
Adrenaline and noradrenaline, known in the science community as epinephrine and norepinephrine, are hormones that are required for the basic "fight or flight" response. Have you ever been scared and had your heart start racing? That is epinephrine being released into your blood and affecting your heart. What would life be like without epineprhine or norepinephrine? You certainly would be rather calm. Using genetic engineering, mice have been made that cannot make epinephrine or norepinephrine. See figure below. Their blood pressures are extremely low! Data were obtained during the night, their active period.
(The code
for the applets is heavily based on the Graph Package created by Leigh
Brookshaw(c)1996 used under the terms of the GNU General Public License).
|
|
|
Copyright
2002 Williams College
|
|