Biology at Williams

Faculty and Staff


Steven Swoap
Steven Swoap
Steven Swoap - Professor
At Williams since 1996


Office: 166 BSC
Phone: (413) 597-3336
E-mail: sswoap@williams.edu
Area of Interest: Physiology



Education
Courses offered
Honors Students
Grants

Research interests

The cardiovascular state of animals is remarkably dependent on the environment. Foraging of food, consumption of food, presence of predators, procuring a mate, ambient temperature, and general activity are just a few examples of external stimuli that have a substantial impact on homeostasis of the cardiovascular system. Research in the Swoap lab examines the underlying mechanisms for cardiovascular adaptations to both changes in ambient temperature and lack of food availability. Our approach is an integrative one; combining molecular biology, thermal physiology, and cardiovascular physiology. Body temperature, blood pressure, and heart rate measurements are made in genetically modified animals using a telemetry-based system. This allows for accurate physiological measurements in animals that are conscious, unrestrained, and freely moving. The use of mice with known germline mutations allows us to directly test hypotheses that relate caloric intake, ambient temperature, and metabolism with cardiovascular function.

Publications

  1. J.R. Shinkle, Steven J. Swoap, P. Simon, R.L. Jones. The cell-wall free space of Cucumis hypocotyls contains NAD and blue-light regulated peroxidase activity, Plant Physiol., 98:1336-1341, 1992.
  2. Steven J. Swoap, S.K. Sooudi, and J.R. Shinkle. Uncorrelated changes in the distribution of stem elongation, tissue extensibility and cell wall peroxidase activity alonghypocotyl axes of Cucumis seedlings exhibiting different patterns of growth, Plant Physiol. Biochem., 31(3): 361-368, 1993.
  3. Steven J. Swoap, T. Johnson, A. Bennett, R. Josephson. Temperature, muscle power output, and limitations on burst locomotor performance of the lizard Dipsosaurus dorsalis, J. Exp. Biol., 174:185-197, 1993. Abstract and PDF here
  4. T. Johnson, Steven J. Swoap, A. Bennett, R. Josephson. Body size, muscle power output, and limitations on burst locomotor performance of the lizard Dipsosaurus dorsalis, J. Exp. Biol., 174:199-213, 1993. Abstract and PDF here
  5. V.J. Caiozzo, Steven J. Swoap, M. Tao, D. Menzel, and K.M. Baldwin. Single fiber analyses of type IIa myosin heavy chain distribution in hyper- and hypothyroid soleus, Amer. J. Physiol., 265:C842-C849, 1993. Abstract and PDF here
  6. Steven J. Swoap, F. Haddad, P. Bodell, and K.M. Baldwin. Effect of chronic energy deprivation on cardiac thyroid receptor and myosin isoform expression, Amer. J. Physiol. 266: E254-E260, 1994. Abstract and PDF here
  7. Steven J. Swoap, F. Haddad, V.J. Caiozzo, S. McCue, and K.M. Baldwin. Interaction of thyroid hormone and functional overload on skeletal muscle isomyosin expression, J. Appl. Physiol.,77(2): 621-629, 1994. Abstract and PDF here
  8. Steven J. Swoap, P. Bodell, and K.M. Baldwin. Interaction of hypertension and caloric restriction on cardiac mass and isomyosin expression, Amer. J. Physiol., 268: R33-R39, 1995. Abstract and PDF here
  9. Steven J. Swoap, F. Haddad, P. Bodell, and K.M. Baldwin. Control of β myosin heavy chain expression in systemic hypertension and caloric restriction in the rat heart, Amer. J. Physiol., 269: C1025-C1033, 1995. Abstract and PDF here
  10. Steven J. Swoap, C. Gastellum, P. Bodell, and K.M. Baldwin. Immunolocalization of rat cardiac β myosin heavy chain protein expression in hypertension and caloric restriction, Amer. J. Physiol., 269: C1034-1041, 1995. Abstract and PDF here
  11. Steven J. Swoap, V.J. Caiozzo, and K.M. Baldwin. Optimal shortening velocities for in situ power production of rat soleus and plantaris muscles, Amer. J. Physiol., 273: C1057-C1063, 1997. Abstract and PDF here
  12. Schultz, R., Steven J. Swoap, L. McDaniel, B. Zhang, E. Koon, D. Garry,K. Li, and R.S. Williams. Differential expression of mitochondrial DNA replication factors in mammalian tissues. J. Biol. Chem. 273(6): 3447-3451, 1998. Abstract and full text here
  13. Steven J. Swoap In vivo analysis of the myosin heavy chain IIB promoter region. Amer. J. Physiol., 274(43): C681-C687, 1998. Abstract and full text here
  14. Kell, R., H.Pierce, and Steven J. Swoap PGAM-M expression is regulated pre-translationally in hindlimb muscles and under altered loading conditions. J. Appl. Phsyiol. 86:236-242, 1999. Abstract and full text here
  15. Wheeler, M.W., E.C. Snyder, M. Patterson, and Steven J. Swoap. An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle. Amer. J. Physiol. 276:C1069-C1078, 1999. Abstract and full text here
  16. Steven J. Swoap, E.J. Stevenson, R.B. Hunter, H. Mitchell-Felton, N.V. Kansagra, J.M. Lang, K.A. Esser, and S.C. Kandarian. The calcineurin-NFAT pathway and muscle fiber-type gene expression. Amer. J. Physiology: 279(4):C915-C924, 2000. Abstract and full text here
  17. D.J. Seward, J.C. Haney, M.A. Rudnicki, and Steven J. Swoap. The bHLH transcription factor MyoD is required for the appropriate regulation of myosin heavy chain IIB expression. Amer. J. Physiology: 280(2):C408-C413, 2001. Abstract and full text here
  18. Steven J. Swoap. Altered leptin signaling is sufficient, but not required, for the hypotension associated with caloric restriction. Amer. J. Physiology: 281(6): H2473-H2479, 2001. Abstract and full text here
  19. Staib, J., Steven J. Swoap, and S. Powers. Diaphragm Contractile Dysfunction in MyoD Gene Inactivated Mice. Amer. J. Physiology.: 283: R583-R590, 2002. Abstract and full text here
  20. Steven J. Swoap, and J.M. Overton. Leptin and Blood Pressure. In "Nutrition and Heart Disease: Causation and Prevention." CRC press, 105-118, 2004.
  21. Steven J. Swoap, D. Weinshenker, R.D. Palmiter, and G. Garber. Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress. Amer. J. Physiology: Regul Integr Comp Physiol 286(1): 108-113, 2004. Abstract and full text here
  22. Steven J. Swoap, J.M. Overton, and G. Garber. Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach. Am J Physiol Regul Integr Comp Physiol. 287(2):R391-6, 2004. Abstract and full text here
  23. Hunt, L.M., E.W. Hogeland, M.K. Henry, and Steven J. Swoap. Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require the ANP receptor. Amer. J. Physiol.: Heart. 287(4): H1446-51, 2004.Abstract and full text here
  24. Acharyya, S., K.J. Ladner, L. L. Nelsen, J. Damrauer, P.J. Reiser, Steven J. Swoap, and D.C. Guttridge. Cancer Cachexia is Regulated by Selective Targeting of Skeletal Muscle Gene Products. J. Clin. Invest.114(3):370-8, 2004. Abstract and full text here
  25. Wisløff, U., S. M. Najjar, Ø. Ellingsen, P. M., Steven J. Swoap, Q. Al-Share, M. Fernström, K. Rezaei, S. J. Lee, L.G. Koch, and S.L. Britton. Cardiovascular Risk Factors Emerge from Artificial Selection for Low Aerobic Capacity in Rats. Science 307: 418-420, 2005.Article and full text here
  26. M.M. Messina, S.A. Evans, Steven J. Swoap, and J.M. Overton. Perinatal MSG treatment attenuates fasting-induced bradycardia and metabolic suppression. Physiology and Behavior, Oct 15; 86(3):324-30, 2005.Article and full text here
  27. Steven J. Swoap, M.J. Gutilla, L.C. Liles, Ross.O. Smith, and D. Weinshenker. The Full Expression of Fasting-Induced Torpor Requires beta3 Adrenergic Receptor Signaling. Journal of Neuroscience, 26: 241-245, 2006.Article and full text here
  28. Knight, W.D., Steven J. Swoap, A. Parsons, and J.M. Overton. Central TRH infusion opposes cardiovascular and metabolic suppression during caloric restriction. Neuroendocrinology, 83(2):69-76, 2006.Article and full text here
  29. Gluck, Elizabeth F., Natalie.Stephens, and Steven J. Swoap. Ghrelin modulates torpor in mice through the Neuropeptide Y signaling pathway. American Journal of Physiology: Regulatory and Integrative, 291 R1303-R1309, 2006.Abstract and full text here
  30. Sowden, Gillian L., D.J. Drucker, D. Weinshenker, and Steven J. Swoap. Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor. American Journal of Physiology: Regulatory and Integrative 292: R962-R970, 2006. Abstract and full text here
  31. Swoap, Steven J., Meaghan Rathvon, Margaret Jean Gutilla.  AMP does not induce torpor.  American Journal of Physiology: Regulatory and Integrative 293: R468–R473, 2007. Abstract and full text here
Undergraduate authors are underlined
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