Here we see how a drug can improve the binding of GABA. When GABA binds to
the receptor, negative chloride ions rush into the cell. This increases
the negative charge inside the postsynaptic cell. Now a tranquilizer,
coming in from the left, binds to the receptor. This changes the
receptor's conformation so GABA binds more tightly. The channel is open for
longer, letting in more chloride ions.