EFFECTS ON THE BODY
Immediate Effects 
Blood level of cocaine is highest about five minutes after taking the drug intravenously or smoking. But when snorted, peak blood levels occur after a larger period of time, approximately fifteen to sixty minutes later.
Cocaine is broken down quickly by the body into inactive byproducts and is almost completely eliminated within 24 hours.
The drug is quickly broken down largely by an enzyme in the blood known as pseudocholinesterase. After being broken down by the pseudocholinesterase cocaine is metabolized into a number of by-products. The most common, benzoylecgonine, is detected in people's urine for up to several days after drug use.
Some people are born without pseudocholinesterase
and a deficiency of this enzyme can cause severe toxic and even fatal reactions
to the smallest amounts of the drug. Other immediate effects that can occur
are listed below...
Heart Attack 
Rapid Irregular Heartbeat (Ventricular Tachycardia or Fibrillation)
Cerebral Hemorrhage
Heatstroke
Seizures
Respiratory Failure
Long-term Effects & Complications--> Generalized Cocaine Effects